[Operator]

Nandrolone is a synthetic anabolic steroid that possesses unique qualities and is potentially beneficial in the treatment of male health alone, or as an adjunct to TST for hypogonadal men. Nandrolone has a relatively long half-life in the plasma and a strong binding affinity for androgen receptors. The lack of conversion to DHT could mean decreased hair loss in men undergoing TST suggesting a novel use for this medication in a subpopulation of hypogonadal men. Furthermore, in men with voiding dysfunction due to benign prostatic hypertrophy, the reduction of nandrolone by 5AR to generate a weaker androgen (compared to DHT) that does not stimulate the growth of androgenic tissues such as the prostate could serve as another indicator for its use. Nandrolone preferentially stimulates growth of skeletal muscle and lean body mass that may provide benefit in reducing components of metabolic syndrome. Moreover, preliminary work on nandrolone has suggested a potential role in the treatment of joint healing, particularly in rotator cuff injuries.

Limitations to the use of nandrolone include the potential for ED via suppression of the HPG axis. The lack of conversion to DHT and the concurrent increase in serum estrogens may mediate this effect. Administration of low doses of testosterone, along with nandrolone, would alleviate these effects. Further research is needed to evaluate nandrolone’s potential role in the management of male health.